Our Science

Cell and genetic engineering have already established a new pillar of medicine for the treatment of cancer. In harnessing the power of regulatory T cells (T_regs) that have shown to have multiple therapeutic and tissue-reparative properties, we are engineering a new generation of cell therapies to have enhanced function and the ability to target specific tissues.

T_regs circulating throughout every tissue type act as sentinels that survey the body for unwanted immune attacks and rebalance the immune system. Our best-in-class T_reg therapies possess multiple therapeutic effects, within a single medicine, to help overcome the complex and multifaceted nature of autoimmune and inflammatory disease.

Emerging research shows that enhanced T_reg cells work directly at the site of inflammation for a durable, lasting response. We are developing T_reg therapies that have the potential to deliver long-lasting efficacy and can target tissues with high specificity. This is a paradigm-shifting approach that can transform treatments for autoimmune and inflammatory diseases.

We are also developing a novel biologic therapy that conditions patients by selectively depleting T effector cells (T_effs). The loss of immune system balance is often caused by uncontrolled inflammation and overactive innate and adaptive immunity, which is correlated with T_eff resistance. By addressing both T_regs and T_effs, Sonoma Bio’s complementary approach holds the potential to induce durable immune system balance and transform the way we treat these diseases.